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  • on 10.06.2010
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Investigators at Haukeland Hospital, Medical Department target serine endopeptidases


According to recent research published in the journal Alimentary Pharmacology & Therapeutics, "An association between atopic disease and gastrointestinal complaints has been suggested. To explore the association between atopic disease, gastrointestinal symptoms, and possible gastrointestinal manifestations of atopic disease in patients with self-reported food hypersensitivity."
"Symptoms, skin prick tests, serum markers of allergy and intestinal permeability were recorded in 71 adult patients. Eosinophils, tryptase- and IgE-positive cells were counted in duodenal biopsies. Sixty-six (93%) patients had irritable bowel syndrome (IBS) and 43 (61%) had atopic disease, predominantly rhinoconjunctivitis. All 43 were sensitized to inhalant allergens, 29 (41%) to food allergens, but food challenges were negative. Serum total IgE and duodenal IgE-positive cell counts were significantly correlated (P < 0.0001) and both were significantly higher in atopic than in non-atopic patients (P < 0.0001 and P = 0.003 respectively). IgE-positive cells appeared to be ‘armed’ mast cells. Intestinal permeability was significantly elevated in atopic compared with non-atopic patients (P = 0.02). Gastrointestinal symptoms and numbers of tryptase-positive mast cells and eosinophils did not differ between groups. Patients with self-reported food hypersensitivity had a high prevalence of IBS and atopic disease," wrote K. Lillestol and colleagues, Haukeland Hospital, Medical Department (see also Serine Endopeptidases).
The researchers concluded: "Atopic patients had increased intestinal permeability and density of IgE-bearing cells compared with non-atopic patients, but gastrointestinal symptoms did not differ between groups."
Lillestol and colleagues published their study in Alimentary Pharmacology & Therapeutics (Indications of ‘atopic bowel’ in patients with self-reported food hypersensitivity. Alimentary Pharmacology & Therapeutics, 2010;31(10):1112-1122).
For additional information, contact K. Lillestol, Haukeland Hospital, Institute Medical, Dept. of Medical, N-5021 Bergen, Norway.
The publisher’s contact information for the journal Alimentary Pharmacology & Therapeutics is: Wiley-Blackwell Publishing, Inc., Commerce Place, 350 Main St., Malden 02148, MA, USA.
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